HRID1454436

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID14797

Potassium hydroxide

HKO

$结构：Cl/C(=C\c1ccc(Br)cc1)c1ccc(Cl)cc1$

HCID57530617

未命名化合物

PRODUCTS

生成物

HCID57530615

1-Bromo-4-[(4-chlorophenyl)ethynyl]benzene

C14H8BrCl

收率 94.1%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

溶剂HCID31275

1,4-Dioxane

C4H8O2

PROCEDURE

实验过程

To a 100 mL flask containing a solution of 1-bromo-4-[(Z) -2-chloro-2-(4-chloro-phenyl) vinyl] benzene (VId) (7.89 g; 24.05 mmol) in 1,4-dioxane (40 mL; 5 vols) and MeOH (12 mL; 1.5 vols), KOH (2.699 g; 48.10 mmol) was added in one portion. Protocol and work-up was then similar with those described above. Title compound (m=6.598 g) was obtained in a 94% yield. Melting point: 179° C.

WORKUP

后处理

additionwas added in one portion