Quinone → HCID 178511962, compound

HRID 1454554Notes

Reaction equation

HRID 1454554 reaction equation
[C:1]([NH:5]C(NCC1C=C(C2C=CC=C(C=O)C=2OCOCCOC)C(OCOCCOC)=CC=1)=O)(C)(C)C.Cl.[NH2:39][C:40]1[C:41](N)=[C:42]([CH:46]=[CH:47][CH:48]=1)[C:43]([NH2:45])=[NH:44].C1(=O)C=CC(=O)C=C1>CO>[NH:5]1[C:48]2[CH:47]=[CH:46][C:42]([C:43]([NH2:45])=[NH:44])=[CH:41][C:40]=2[N:39]=[CH:1]1

Participants

5

Reactant 3

HCID 4650QuinoneHCID 22556984HCID 22556984, compoundHCID 86607736HCID 86607736, compound

Product 1

HCID 178511962HCID 178511962, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
60 °C

Procedure

1-tert-Butyl-3-[3′-formyl-6,2′-bis-(2-methoxyethoxymethoxy)-biphenyl-3-ylmethyl]-urea (0.6 g, 1.15 mmol), prepared as in Reference 19, diaminobenzamidine hydrochloride (0.3 g, 1.6 mmol) and 1,4-benzoquinone (0.124 g, 1.15 mmol) were combined in methanol (15 mL) and the mixture was heated at 60° C. and stirred for 2 hours. The mixture was cooled to room temperature and the solvent was removed by evaporation to yield 2-[5′-3-tert-butylureidomethyl)-2,2′- bis-(2-methoxyethoxymethoxy)-biphenyl-3-yl]-1H-benzoimidazole-5-carboxamidine.

Workup

  1. temperatureThe mixture was cooled to room temperature
  2. customthe solvent was removed by evaporation

Sources & evidence

ORD record
ord-3b55ea578aaf4140be25a9afac0a8d45
Source dataset
uspto-grants-2009_01
Patent number
US07479502B2

Reaction notes

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