HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butoxycarbonylalanine → 1,1-dimethylethyl 1-[6-chloro-1-[4-(2-hydroxyethyl)phenyl]-5-(trifluoromethyl)-1H-benzimidazol-2-yl]ethylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butoxycarbonylalanine | HCID 85082 | — |
| Reactant | 2-(4-{[2-Amino-5-chloro-4-(trifluoromethyl)phenyl]amino}phenyl)ethyl acetate | HCID 21875555 | — |
| Product | 1,1-dimethylethyl 1-[6-chloro-1-[4-(2-hydroxyethyl)phenyl]-5-(trifluoromethyl)-1H-benzimidazol-2-yl]ethylcarbamate | HCID 21876056 | — |
Reaction Steps
The title compound was prepared according to the procedure described in Example 339, step 3 & Example 1, step 5 from N-(tert-butoxycarbonyl)-alanine and 2-(4-{[2-amino-5-chloro-4-(trifluoromethyl)phenyl]amino}phenyl)ethyl acetate (Example 339, step 2).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07479564B2 |
| Source dataset | uspto-grants-2009_01 |
| ORD ID | ord-296b6971926641a381138619530ee840 |
| Source note | uspto-grants-2009_01 |