Isopentyltriphenylphosphonium bromide → 3-Oxo-2-cyanopropanoic acid n-octyl ester isoamyltriphenylphosphonium salt

HRID 1454749Notes

Reaction equation

HRID 1454749 reaction equation
[K].[CH2:2]([O:10][C:11](=[O:17])[CH:12]([C:15]#[N:16])[CH:13]=[O:14])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9].[Br-].[CH2:19]([P+:24]([C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1)([C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[CH2:20][CH:21]([CH3:23])[CH3:22]>>[CH2:19]([P+:24]([C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1)([C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1)[C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)[CH2:20][CH:21]([CH3:23])[CH3:22].[CH2:2]([O:10][C:11](=[O:17])[CH:12]([C:15]#[N:16])[CH:13]=[O:14])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9]

Participants

4

Reactant 3

HCID 2759379Isopentyltriphenylphosphonium bromideHCID 5462222PotassiumHCID 866208103-Oxo-2-cyanopropanoic acid n-octyl ester

Product 1

HCID 866208093-Oxo-2-cyanopropanoic acid n-octyl ester isoamyltriphenylphosphonium salt

Procedure

CDP-8 was prepared similar to the method used to prepare CDP-2 from potassium salt of 3-oxo-2-cyanopropanoic acid n-octyl ester and isoamyltriphenylphosphonium bromide in quantitative yield as a viscose orange color oily residue.

Workup

  1. customwas prepared similar to the method

Sources & evidence

ORD record
ord-ddbf3463a06c4f38b63a00d0409b8614
Source dataset
uspto-grants-2009_01
Patent number
US07482113B2

Reaction notes

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