Sodium borohydride → HCID 57530960, compound

Participants

Reaction Conditions

Reaction Steps

2-Fluoro-6-[(4,6-dimethoxypyrimidin-2-yl)carbonyl]aniline 2.68 g (9.67 mmol) was dissolved in methanol 80 ml and, after cooling it to 5° C., sodium borohydride 0.73 g (19.33 mmol) was added thereto while stirring. Then the solution was stirred at room temperature for 2 hours. The reaction solution was distilled off under reduced pressure and the obtained crystals were dissolved in water and dichloromethane. The organic layer was separated and the water layer was further extracted three times with dichloromethane. After the organic layer had been washed with water and dried, dichloromethane was distilled off under reduced pressure to obtain the objective 2-fluoro-6-[(4,6-dimethoxypyrimidin-2-yl)hydroxymethyl]aniline 2.66 g (yield 98%) as white crystals.

Provenance & Evidence