[1,2,4]Triazolo[1,5-a]pyrazine → 5H,6H,7H,8H-(1,2,4)triazolo(1,5-a)pyrazine

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Reaction Steps

A mixture of [1,2,4]triazolo[1,5-a]pyrazine (10 g) in ethanol (150 mL) and 10% Pd-C (3 g) was stirred under a hydrogen atmosphere overnight and filtered over Celite®. The filtrate was evaporated and the residue purified by column chromatography (silica, 10% methanol/dichloromethane) to yield 5,6,7,8-tetrahydro[1,2,4]triazolo[1,5-a]pyrazine. LC-MS 125.1 (M+1).

Provenance & Evidence