Trifluoroacetic acid → HCID 60019900, compound

Participants

Reaction Conditions

Reaction Steps

(6-Diethylcarbamoylmethyl-pyridin-2-yl)-carbamic acid tert-butyl ester (0.2 g) in CH2Cl2 (10 mL) was treated at RT with trifluoro-acetic acid (0.5 mL) and the solution was stirred for 1.5 h until the reaction was complete according to the analysis. The mixture was allowed to warm to 10° C. and partitioned between aqueous diluted KHCO3 and AcOEt, the layers were separated, the organic layer dried over Na2SO4, filtered, evaporated to give 2-(6-amino-pyridin-2-yl)-N,N-diethyl-acetamide (148 mg) as a light yellow solid that was directly used in the next step.

Provenance & Evidence