Potassium Carbonate → HCID 68842242, compound

Participants

Reaction Steps

(5-Bromo-6-diethylcarbamoylmethyl-pyridin-2-yl)-carbamic acid tert-butyl ester (0.116 g in dioxane (5 mL) was treated successively at RT with potassium carbonate (0.124 g), tetrakis(triphenylphosphine) palladium(0), 35 mg, and trimethylboroxine (38 mg) and then heated to reflux for 22 h. The mixture was cooled to RT, filtered and the filter cake washed with AcOEt. The filtrate was concentrated in vacuo, the residue purified by flash chromatography (heptane/AcOEt 1:1 to 1:4) to give (6-diethylcarbamoylmethyl-5-methyl-pyridin-2-yl)-carbamic acid tert-butyl ester (37 mg) as a colorless gum. MS (ESI): 322.4 (MH+).

Provenance & Evidence