反应详情

温度

100 °C

N-(6-cyclopropylmethoxymethyl-pyridin-2-yl)-2,2-dimethyl-propionamide (0.884 g) in ethanol (50 mL) was treated at RT with 3M aqueous NaOH (5.62 mL) and then heated at 100° C. for 20 h. The mixture was cooled to RT, partitioned between water and AcOEt. The layers were separated, the organic layer dried over magnesium sulphate, filtered and evaporated in vacuo to give 6-cyclopropylmethoxymethyl-pyridin-2-ylamine (0.566 g) as a light brown liquid. MS (ESI): 179.1 (MH+).

1. temperatureThe mixture was cooled to RT
2. custompartitioned between water and AcOEt
3. customThe layers were separated
4. dry with materialthe organic layer dried over magnesium sulphate
5. filtrationfiltered
6. customevaporated in vacuo