3-Chloro-2-methylbenzenesulfonyl chloride → 3-Chloro-N-[6-(4-fluoro-benzyloxymethyl)-pyridin-2-yl]-2-methyl-benzenesulfonamide

HRID 1454824Notes

Reaction equation

HRID 1454824 reaction equation
[F:1][C:2]1[CH:17]=[CH:16][C:5]([CH2:6][O:7][CH2:8][C:9]2[N:14]=[C:13]([NH2:15])[CH:12]=[CH:11][CH:10]=2)=[CH:4][CH:3]=1.[Cl:18][C:19]1[C:20]([CH3:29])=[C:21]([S:25](Cl)(=[O:27])=[O:26])[CH:22]=[CH:23][CH:24]=1>>[Cl:18][C:19]1[C:20]([CH3:29])=[C:21]([S:25]([NH:15][C:13]2[CH:12]=[CH:11][CH:10]=[C:9]([CH2:8][O:7][CH2:6][C:5]3[CH:4]=[CH:3][C:2]([F:1])=[CH:17][CH:16]=3)[N:14]=2)(=[O:27])=[O:26])[CH:22]=[CH:23][CH:24]=1

Participants

3

Reactant 2

HCID 5227343-Chloro-2-methylbenzenesulfonyl chlorideHCID 688451406-(4-Fluoro-benzyloxymethyl)-pyridin-2-ylamine

Product 1

HCID 116761333-Chloro-N-[6-(4-fluoro-benzyloxymethyl)-pyridin-2-yl]-2-methyl-benzenesulfonamide

Procedure

This material was prepared in analogy to example 1 from 6-(4-fluoro-benzyloxymethyl)-pyridin-2-ylamine (0.058 g) and 3-chloro-2-methyl-benzenesulfonyl chloride (0.062 g) as a light yellow gum (0.087 g). MS (ESI−): 419.0. ([M−H]−)

Sources & evidence

ORD record
ord-a8527844bdc24f7bbfb77e8b3237ce34
Source dataset
uspto-grants-2009_01
Patent number
US07482341B2

Reaction notes

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