5-Fluoro-2-methylbenzenesulphonyl chloride → HCID 11704846, compound

HRID 1454832Notes

Reaction equation

HRID 1454832 reaction equation
[F:1][C:2]([F:19])([F:18])[C:3]1[CH:17]=[CH:16][C:6]([O:7][CH2:8][C:9]2[N:14]=[C:13]([NH2:15])[CH:12]=[CH:11][CH:10]=2)=[CH:5][CH:4]=1.[F:20][C:21]1[CH:22]=[CH:23][C:24]([CH3:31])=[C:25]([S:27](Cl)(=[O:29])=[O:28])[CH:26]=1>>[F:20][C:21]1[CH:22]=[CH:23][C:24]([CH3:31])=[C:25]([S:27]([NH:15][C:13]2[CH:12]=[CH:11][CH:10]=[C:9]([CH2:8][O:7][C:6]3[CH:16]=[CH:17][C:3]([C:2]([F:1])([F:18])[F:19])=[CH:4][CH:5]=3)[N:14]=2)(=[O:29])=[O:28])[CH:26]=1

Participants

3

Reactant 2

HCID 1362865-Fluoro-2-methylbenzenesulphonyl chlorideHCID 68842874HCID 68842874, compound

Product 1

HCID 11704846HCID 11704846, compound

Procedure

This material was prepared in analogy to example 1 from 6-(4-trifluoromethyl-phenoxymethyl)-pyridin-2-ylamine (0.08 g) and 5-fluoro-2-methyl-benzenesulfonyl chloride (0.07 g) as a light yellow solid (0.1 g). MS (ESI−): 439.1 ([M−H]−)

Sources & evidence

ORD record
ord-17ee0a67b7ac4ed58abe2ee9a5e7ddbd
Source dataset
uspto-grants-2009_01
Patent number
US07482341B2

Reaction notes

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