3-(Trifluoromethyl)benzenesulfonyl chloride → HCID 11611930, compound

HRID 1454834Notes

Reaction equation

HRID 1454834 reaction equation
[F:1][C:2]1[CH:17]=[CH:16][C:5]([CH2:6][O:7][CH2:8][C:9]2[N:14]=[C:13]([NH2:15])[CH:12]=[CH:11][CH:10]=2)=[CH:4][CH:3]=1.[F:18][C:19]([F:31])([F:30])[C:20]1[CH:21]=[C:22]([S:26](Cl)(=[O:28])=[O:27])[CH:23]=[CH:24][CH:25]=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][O:7][CH2:8][C:9]2[N:14]=[C:13]([NH:15][S:26]([C:22]3[CH:23]=[CH:24][CH:25]=[C:20]([C:19]([F:18])([F:30])[F:31])[CH:21]=3)(=[O:28])=[O:27])[CH:12]=[CH:11][CH:10]=2)=[CH:16][CH:17]=1

Participants

3

Reactant 2

HCID 27332503-(Trifluoromethyl)benzenesulfonyl chlorideHCID 688451406-(4-Fluoro-benzyloxymethyl)-pyridin-2-ylamine

Product 1

HCID 11611930HCID 11611930, compound

Procedure

This material was prepared in analogy to example 1 from 6-(4-fluoro-benzyloxymethyl)-pyridin-2-ylamine (0.058 g) and 3-(trifluoromethyl)-benzenesulfonyl chloride (0.067 g) as a light yellow gum (0.08g). MS (ESI−): 439.1 ([M−H]−)

Sources & evidence

ORD record
ord-9349110813ab459ea4d02b791f988c6f
Source dataset
uspto-grants-2009_01
Patent number
US07482341B2

Reaction notes

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