Sodium Hydroxide → 5-Cyclopropylmethoxymethyl-6-methyl-pyridin-2-ylamine

HRID 1454844Notes

Reaction equation

[CH:1]1([CH2:4][O:5][CH2:6][C:7]2[CH:8]=[CH:9][C:10]([NH:14]C(=O)C(C)(C)C)=[N:11][C:12]=2[CH3:13])[CH2:3][CH2:2]1.[OH-].[Na+]>>[CH:1]1([CH2:4][O:5][CH2:6][C:7]2[CH:8]=[CH:9][C:10]([NH2:14])=[N:11][C:12]=2[CH3:13])[CH2:3][CH2:2]1

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 68843080N-(5-Cyclopropylmethoxymethyl-6-methyl-pyridin-2-yl)-2,2-dimethyl-propionamide

Product 1

HCID 688431485-Cyclopropylmethoxymethyl-6-methyl-pyridin-2-ylamine

Procedure

This material was prepared in analogy to example 86 step B] from N-(5-cyclopropylmethoxymethyl-6-methyl-pyridin-2-yl)-2,2-dimethyl-propionamide (0.357 g) and 3M aqueous NaOH (2.68 mL) as a dark red oil (0.163 g). MS (EI): 192.2 (M+).

Sources & evidence

ORD record: ord-4cd94311109942f087bb4cee0b685f0b
Source dataset: uspto-grants-2009_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07482341B2

Reaction notes

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