3-Chloro-2-methylbenzenesulfonyl chloride → 3-Chloro-N-(5-cyclopropylmethoxymethyl-6-methyl-pyridin-2-yl)-2-methyl-benzenesulfonamide

HRID 1454845Notes

Reaction equation

HRID 1454845 reaction equation
[CH:1]1([CH2:4][O:5][CH2:6][C:7]2[CH:8]=[CH:9][C:10]([NH2:14])=[N:11][C:12]=2[CH3:13])[CH2:3][CH2:2]1.[Cl:15][C:16]1[C:17]([CH3:26])=[C:18]([S:22](Cl)(=[O:24])=[O:23])[CH:19]=[CH:20][CH:21]=1>>[Cl:15][C:16]1[C:17]([CH3:26])=[C:18]([S:22]([NH:14][C:10]2[CH:9]=[CH:8][C:7]([CH2:6][O:5][CH2:4][CH:1]3[CH2:3][CH2:2]3)=[C:12]([CH3:13])[N:11]=2)(=[O:24])=[O:23])[CH:19]=[CH:20][CH:21]=1

Participants

3

Reactant 2

HCID 5227343-Chloro-2-methylbenzenesulfonyl chlorideHCID 688431485-Cyclopropylmethoxymethyl-6-methyl-pyridin-2-ylamine

Product 1

HCID 688411543-Chloro-N-(5-cyclopropylmethoxymethyl-6-methyl-pyridin-2-yl)-2-methyl-benzenesulfonamide

Procedure

This material was prepared in analogy to example 1 from 5-cyclopropylmethoxymethyl-6-methyl-pyridin-2-ylamine (0.053 g) and 3-chloro-2-methyl-benzenesulfonyl chloride (0.058 g) as a light brown solid (0.046 g). MS (ESI−): 379.1 ([M−H]−)

Sources & evidence

ORD record
ord-d8ce8aef248b4841a7b11eb8d13b91b5
Source dataset
uspto-grants-2009_01
Patent number
US07482341B2

Reaction notes

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