Methyl iodide → N-(5-Methoxymethyl-6-methyl-pyridin-2-yl)-2,2-dimethyl-propionamide

HRID 1454848Notes

Reaction equation

[OH:1][CH2:2][C:3]1[CH:4]=[CH:5][C:6]([NH:10][C:11](=[O:16])[C:12]([CH3:15])([CH3:14])[CH3:13])=[N:7][C:8]=1[CH3:9].I[CH3:18]>>[CH3:18][O:1][CH2:2][C:3]1[CH:4]=[CH:5][C:6]([NH:10][C:11](=[O:16])[C:12]([CH3:13])([CH3:15])[CH3:14])=[N:7][C:8]=1[CH3:9]

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 68844472N-(5-Hydroxymethyl-6-methyl-pyridin-2-yl)-2,2-dimethyl-propionamide2×

Product 1

HCID 68841136N-(5-Methoxymethyl-6-methyl-pyridin-2-yl)-2,2-dimethyl-propionamide

Procedure

This material was prepared in analogy to example 86 step A] from N-(5-hydroxymethyl-6-methyl-pyridin-2-yl)-2,2-dimethyl-propionamide (0.6 g, product of example 112 step B]) and iodomethane (0.421 g) as a white solid (0.4 g). MS (ESI): 237.2 (MH+).

Sources & evidence

ORD record: ord-41977ac6a09e4453b08eac7c1559f1ec
Source dataset: uspto-grants-2009_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07482341B2

Reaction notes

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