Sodium Hydroxide → 5-(4-Fluoro-benzyloxymethyl)-6-methyl-pyridin-2-ylamine

HRID 1454853Notes

Reaction equation

HRID 1454853 reaction equation
[F:1][C:2]1[CH:24]=[CH:23][C:5]([CH2:6][O:7][CH2:8][C:9]2[CH:10]=[CH:11][C:12]([NH:16]C(=O)C(C)(C)C)=[N:13][C:14]=2[CH3:15])=[CH:4][CH:3]=1.[OH-].[Na+]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][O:7][CH2:8][C:9]2[CH:10]=[CH:11][C:12]([NH2:16])=[N:13][C:14]=2[CH3:15])=[CH:23][CH:24]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 68842559N-[5-(4-Fluoro-benzyloxymethyl)-6-methyl-pyridin-2-yl]-2,2-dimethyl-propionamide

Product 1

HCID 688410345-(4-Fluoro-benzyloxymethyl)-6-methyl-pyridin-2-ylamine

Procedure

This material was prepared in analogy to example 86 step B] from N-[5-(4-Fluoro-benzyloxymethyl)-6-methyl-pyridin-2-yl]-2,2-dimethyl-propionamide (0.78 g) and 3M aqueous NaOH (3.93 mL) as an amorphous orange solid (0.58 g). MS (ESI): 247.2 (MH+).

Sources & evidence

ORD record
ord-cfe4e35e0dd64635b46c4097642d8d26
Source dataset
uspto-grants-2009_01
Patent number
US07482341B2

Reaction notes

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