3-(Trifluoromethyl)benzenesulfonyl chloride → N-[5-(4-Fluoro-benzyloxymethyl)-6-methyl-pyridin-2-yl]-3-trifluoromethyl-benzenesulfonamide

HRID 1454854Notes

Reaction equation

HRID 1454854 reaction equation
[F:1][C:2]1[CH:18]=[CH:17][C:5]([CH2:6][O:7][CH2:8][C:9]2[CH:10]=[CH:11][C:12]([NH2:16])=[N:13][C:14]=2[CH3:15])=[CH:4][CH:3]=1.[F:19][C:20]([F:32])([F:31])[C:21]1[CH:22]=[C:23]([S:27](Cl)(=[O:29])=[O:28])[CH:24]=[CH:25][CH:26]=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][O:7][CH2:8][C:9]2[CH:10]=[CH:11][C:12]([NH:16][S:27]([C:23]3[CH:24]=[CH:25][CH:26]=[C:21]([C:20]([F:19])([F:31])[F:32])[CH:22]=3)(=[O:29])=[O:28])=[N:13][C:14]=2[CH3:15])=[CH:17][CH:18]=1

Participants

3

Reactant 2

HCID 27332503-(Trifluoromethyl)benzenesulfonyl chlorideHCID 688410345-(4-Fluoro-benzyloxymethyl)-6-methyl-pyridin-2-ylamine

Product 1

HCID 68842156N-[5-(4-Fluoro-benzyloxymethyl)-6-methyl-pyridin-2-yl]-3-trifluoromethyl-benzenesulfonamide

Procedure

This material was prepared in analogy to example 1 from 5-(4-fluoro-benzyloxymethyl)-6-methyl-pyridin-2-ylamine (0.08 g) and 3-(trifluoromethyl)-benzenesulfonyl chloride (0.087 g) as an amorphous orange solid (0.1 g). MS (ESI−): 453.2 ([M−H]−)

Sources & evidence

ORD record
ord-78c5fccd0102497f87c1b1df8392da3b
Source dataset
uspto-grants-2009_01
Patent number
US07482341B2

Reaction notes

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