3-Chloro-2-methylbenzenesulfonyl chloride → 3-Chloro-N-[5-(4-fluoro-benzyloxymethyl)-6-methyl-pyridin-2-yl)-2-methyl-benzenesulfonamide

HRID 1454855Notes

Reaction equation

HRID 1454855 reaction equation
[F:1][C:2]1[CH:18]=[CH:17][C:5]([CH2:6][O:7][CH2:8][C:9]2[CH:10]=[CH:11][C:12]([NH2:16])=[N:13][C:14]=2[CH3:15])=[CH:4][CH:3]=1.[Cl:19][C:20]1[C:21]([CH3:30])=[C:22]([S:26](Cl)(=[O:28])=[O:27])[CH:23]=[CH:24][CH:25]=1>>[Cl:19][C:20]1[C:21]([CH3:30])=[C:22]([S:26]([NH:16][C:12]2[CH:11]=[CH:10][C:9]([CH2:8][O:7][CH2:6][C:5]3[CH:4]=[CH:3][C:2]([F:1])=[CH:18][CH:17]=3)=[C:14]([CH3:15])[N:13]=2)(=[O:28])=[O:27])[CH:23]=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 5227343-Chloro-2-methylbenzenesulfonyl chlorideHCID 688410345-(4-Fluoro-benzyloxymethyl)-6-methyl-pyridin-2-ylamine

Product 1

HCID 688453143-Chloro-N-[5-(4-fluoro-benzyloxymethyl)-6-methyl-pyridin-2-yl)-2-methyl-benzenesulfonamide

Procedure

This material was prepared in analogy to example 1 from 5-(4-fluoro-benzyloxymethyl)-6-methyl-pyridin-2-ylamine (0.08 g) and 3-chloro-2-methyl-benzenesulfonyl chloride (0.08 g) as an amorphous light yellow solid (0.067 g). MS (ESI−): 433.1 ([M−H]−)

Sources & evidence

ORD record
ord-c57e6423bf4244ada4cabea7bc1e093b
Source dataset
uspto-grants-2009_01
Patent number
US07482341B2

Reaction notes

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