3-(Trifluoromethyl)benzenesulfonyl chloride → N-(5-Ethoxymethyl-6-methyl-pyridin-2-yl)-3-trifluoromethyl-benzenesulfonamide

HRID 1454858Notes

Reaction equation

HRID 1454858 reaction equation
[CH2:1]([O:3][CH2:4][C:5]1[CH:6]=[CH:7][C:8]([NH2:12])=[N:9][C:10]=1[CH3:11])[CH3:2].[F:13][C:14]([F:26])([F:25])[C:15]1[CH:16]=[C:17]([S:21](Cl)(=[O:23])=[O:22])[CH:18]=[CH:19][CH:20]=1>>[CH2:1]([O:3][CH2:4][C:5]1[CH:6]=[CH:7][C:8]([NH:12][S:21]([C:17]2[CH:18]=[CH:19][CH:20]=[C:15]([C:14]([F:13])([F:25])[F:26])[CH:16]=2)(=[O:23])=[O:22])=[N:9][C:10]=1[CH3:11])[CH3:2]

Participants

3

Reactant 2

HCID 27332503-(Trifluoromethyl)benzenesulfonyl chlorideHCID 688408275-Ethoxymethyl-6-methyl-pyridin-2-ylamine

Product 1

HCID 68845113N-(5-Ethoxymethyl-6-methyl-pyridin-2-yl)-3-trifluoromethyl-benzenesulfonamide

Procedure

This material was prepared in analogy to example 1 from 5-Ethoxymethyl-6-methyl-pyridin-2-ylamine (0.066 g) and 3-(trifluoromethyl)-benzenesulfonyl chloride (0.108 g) as a light yellow solid (0.115 g). MS (ESI−): 373.1 ([M−H]−)

Sources & evidence

ORD record
ord-72af9b81b7cb4768833f898d40b337e8
Source dataset
uspto-grants-2009_01
Patent number
US07482341B2

Reaction notes

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