反应详情

N-(6-Hydroxymethyl-pyridin-2-yl)-2,2-dimethyl-propionamide (2.03 g) in CH2Cl2 (75 mL) was treated at RT with thionyl chloride (1.785 mL) and then heated to reflux for 1.5 h. The reaction mixture was cooled to RT and partitioned between water and AcOEt, the layers were separated, the organic layer dried over MgSO4, filtered and evaporated to give N-(6-chloromethyl-pyridin-2-yl)-2,2-dimethyl-propionamide (0.66 g) as a brown liquid. MS (ESI): 227.2 (MH+).

1. temperatureheated
2. temperatureto reflux for 1.5 h
3. custompartitioned between water and AcOEt
4. customthe layers were separated
5. dry with materialthe organic layer dried over MgSO4
6. filtrationfiltered
7. customevaporated