3,5-Bis(trifluoromethyl)benzenesulphonyl chloride → N-(5-Ethoxymethyl-6-methyl-pyridin-2-yl)-3,5-bis-trifluoromethyl-benzenesulfonamide

HRID 1454865Notes

Reaction equation

HRID 1454865 reaction equation
[CH2:1]([O:3][CH2:4][C:5]1[CH:6]=[CH:7][C:8]([NH2:12])=[N:9][C:10]=1[CH3:11])[CH3:2].[F:13][C:14]([F:30])([F:29])[C:15]1[CH:16]=[C:17]([S:25](Cl)(=[O:27])=[O:26])[CH:18]=[C:19]([C:21]([F:24])([F:23])[F:22])[CH:20]=1>>[CH2:1]([O:3][CH2:4][C:5]1[CH:6]=[CH:7][C:8]([NH:12][S:25]([C:17]2[CH:18]=[C:19]([C:21]([F:22])([F:23])[F:24])[CH:20]=[C:15]([C:14]([F:13])([F:29])[F:30])[CH:16]=2)(=[O:27])=[O:26])=[N:9][C:10]=1[CH3:11])[CH3:2]

Participants

3

Reactant 2

HCID 5209453,5-Bis(trifluoromethyl)benzenesulphonyl chlorideHCID 688408275-Ethoxymethyl-6-methyl-pyridin-2-ylamine

Product 1

HCID 86604236N-(5-Ethoxymethyl-6-methyl-pyridin-2-yl)-3,5-bis-trifluoromethyl-benzenesulfonamide

Procedure

This material was prepared in analogy to example 1 from 5-ethoxymethyl-6-methyl-pyridin-2-ylamine (0.07 g) and 3,5-di(trifluoromethyl)-benzenesulfonyl chloride (0.145 g) as an off-white solid (0.032 g). MS (ESI−): 441.1 ([M−H]−)

Sources & evidence

ORD record
ord-ddbb662a33dd452daff5e1c462faf53c
Source dataset
uspto-grants-2009_01
Patent number
US07482341B2

Reaction notes

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