4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride → 4-Chloro-N-(5-ethoxymethyl-6-methyl-pyridin-2-yl)-3-trifluoromethyl-benzenesulfonamide
Reaction equation
[CH2:1]([O:3][CH2:4][C:5]1[CH:6]=[CH:7][C:8]([NH2:12])=[N:9][C:10]=1[CH3:11])[CH3:2].[Cl:13][C:14]1[CH:19]=[CH:18][C:17]([S:20](Cl)(=[O:22])=[O:21])=[CH:16][C:15]=1[C:24]([F:27])([F:26])[F:25]>>[Cl:13][C:14]1[CH:19]=[CH:18][C:17]([S:20]([NH:12][C:8]2[CH:7]=[CH:6][C:5]([CH2:4][O:3][CH2:1][CH3:2])=[C:10]([CH3:11])[N:9]=2)(=[O:21])=[O:22])=[CH:16][C:15]=1[C:24]([F:27])([F:25])[F:26]Participants
3
Procedure
This material was prepared in analogy to example 1 from 5-ethoxymethyl-6-methyl-pyridin-2-ylamine (0.07 g) and 4-chloro-3-(trifluoromethyl)- benzenesulfonyl chloride (0.129 g) as a yellow gum (0.068 g). MS (ESI−): 407.2 ([M−H]−)
Sources & evidence
- ORD record
- ord-e4ccedf4387c43ff84fc1c33715de2b9
- Source dataset
- uspto-grants-2009_01
- Patent number
- US07482341B2
Reaction notes
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