4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride → HCID 68842153, compound

HRID 1454867Notes

Reaction equation

HRID 1454867 reaction equation
[F:1][C:2]1[CH:17]=[CH:16][C:5]([CH2:6][O:7][CH2:8][C:9]2[N:14]=[C:13]([NH2:15])[CH:12]=[CH:11][CH:10]=2)=[CH:4][CH:3]=1.[Cl:18][C:19]1[CH:24]=[CH:23][C:22]([S:25](Cl)(=[O:27])=[O:26])=[CH:21][C:20]=1[C:29]([F:32])([F:31])[F:30]>>[Cl:18][C:19]1[CH:24]=[CH:23][C:22]([S:25]([NH:15][C:13]2[CH:12]=[CH:11][CH:10]=[C:9]([CH2:8][O:7][CH2:6][C:5]3[CH:4]=[CH:3][C:2]([F:1])=[CH:17][CH:16]=3)[N:14]=2)(=[O:26])=[O:27])=[CH:21][C:20]=1[C:29]([F:32])([F:30])[F:31]

Participants

3

Reactant 2

HCID 27807194-Chloro-3-(trifluoromethyl)benzenesulfonyl ChlorideHCID 688451406-(4-Fluoro-benzyloxymethyl)-pyridin-2-ylamine

Product 1

HCID 68842153HCID 68842153, compound

Procedure

This material was prepared in analogy to example 1 from 6-(4-fluoro-benzyloxymethyl)-pyridin-2-ylamine (0.058 g) and 4-chloro-3-(trifluoromethyl)-benzenesulfonyl chloride (0.077 g) as a light yellow gum (0.084 g). MS (ESI−): 472.8 ([M−H]−)

Sources & evidence

ORD record
ord-1ee9aa590b8a42209c34e71493f1b315
Source dataset
uspto-grants-2009_01
Patent number
US07482341B2

Reaction notes

Loading…