3-(Trifluoromethyl)benzenesulfonyl chloride → N-[5-(2-Fluoro-ethoxymethyl)-6-methyl-pyridin-2-yl]-3-trifluoromethyl-benzenesulfonamide
Reaction equation
[F:1][CH2:2][CH2:3][O:4][CH2:5][C:6]1[CH:7]=[CH:8][C:9]([NH2:13])=[N:10][C:11]=1[CH3:12].[F:14][C:15]([F:27])([F:26])[C:16]1[CH:17]=[C:18]([S:22](Cl)(=[O:24])=[O:23])[CH:19]=[CH:20][CH:21]=1>>[F:1][CH2:2][CH2:3][O:4][CH2:5][C:6]1[CH:7]=[CH:8][C:9]([NH:13][S:22]([C:18]2[CH:19]=[CH:20][CH:21]=[C:16]([C:15]([F:14])([F:26])[F:27])[CH:17]=2)(=[O:24])=[O:23])=[N:10][C:11]=1[CH3:12]Participants
3
Procedure
This material was prepared in analogy to example 1 from 5-(2-fluoro-ethoxymethyl)-6-methyl-pyridin-2-ylamine (0.05 g) and 3-(trifluoromethyl)-benzenesulfonyl chloride (0.073 g) as a light yellow gum (39 mg g). MS (ESI−): 391.2 ([M−H]−)
Sources & evidence
- ORD record
- ord-bbb9492f8db94c9e935039d7865515b4
- Source dataset
- uspto-grants-2009_01
- Patent number
- US07482341B2
Reaction notes
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