3-Chlorobenzenesulphonyl chloride → 3-Chloro-N-(5-cyclopropylmethoxymethyl-pyridin-2-yl)-benzenesulfonamide

HRID 1454873Notes

Reaction equation

HRID 1454873 reaction equation
[CH:1]1([CH2:4][O:5][CH2:6][C:7]2[CH:8]=[CH:9][C:10]([NH2:13])=[N:11][CH:12]=2)[CH2:3][CH2:2]1.[Cl:14][C:15]1[CH:16]=[C:17]([S:21](Cl)(=[O:23])=[O:22])[CH:18]=[CH:19][CH:20]=1>>[Cl:14][C:15]1[CH:16]=[C:17]([S:21]([NH:13][C:10]2[CH:9]=[CH:8][C:7]([CH2:6][O:5][CH2:4][CH:1]3[CH2:3][CH2:2]3)=[CH:12][N:11]=2)(=[O:23])=[O:22])[CH:18]=[CH:19][CH:20]=1

Participants

3

Reactant 2

HCID 179093-Chlorobenzenesulphonyl chlorideHCID 621942995-Cyclopropylmethoxymethyl-pyridin-2-ylamine

Product 1

HCID 688456913-Chloro-N-(5-cyclopropylmethoxymethyl-pyridin-2-yl)-benzenesulfonamide

Procedure

This material was prepared in analogy to example 1 from 5-cyclopropylmethoxymethyl-pyridin-2-ylamine (0.06 g) and 3-chloro-benzenesulfonyl chloride (0.078 g) as an amorphous off-white solid (0.059 g). MS (ESI−): 351.1 ([M−H]−)

Sources & evidence

ORD record
ord-0d00ea583d654c87969edd35e548e2df
Source dataset
uspto-grants-2009_01
Patent number
US07482341B2

Reaction notes

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