2,4-Dichloro-6-methylbenzenesulfonyl chloride → 2,4-Dichloro-N-(5-cyclopropylmethoxymethyl-pyridin-2-yl)-6-methyl-benzenesulfonamide

HRID 1454874Notes

Reaction equation

HRID 1454874 reaction equation
[CH:1]1([CH2:4][O:5][CH2:6][C:7]2[CH:8]=[CH:9][C:10]([NH2:13])=[N:11][CH:12]=2)[CH2:3][CH2:2]1.[Cl:14][C:15]1[CH:20]=[C:19]([Cl:21])[CH:18]=[C:17]([CH3:22])[C:16]=1[S:23](Cl)(=[O:25])=[O:24]>>[Cl:14][C:15]1[CH:20]=[C:19]([Cl:21])[CH:18]=[C:17]([CH3:22])[C:16]=1[S:23]([NH:13][C:10]1[CH:9]=[CH:8][C:7]([CH2:6][O:5][CH2:4][CH:1]2[CH2:3][CH2:2]2)=[CH:12][N:11]=1)(=[O:25])=[O:24]

Participants

3

Reactant 2

HCID 28013872,4-Dichloro-6-methylbenzenesulfonyl chlorideHCID 621942995-Cyclopropylmethoxymethyl-pyridin-2-ylamine

Product 1

HCID 688421932,4-Dichloro-N-(5-cyclopropylmethoxymethyl-pyridin-2-yl)-6-methyl-benzenesulfonamide

Procedure

This material was prepared in analogy to example 1 from 5-cyclopropylmethoxymethyl-pyridin-2-ylamine (0.06 g) and 2,4-dichloro-6-methyl-benzenesulfonyl chloride (0.096 g) as an off-white solid (0.069 g). MS (ESI−): 399.1 ([M−H]−)

Sources & evidence

ORD record
ord-22553e7069f649b48f1fef0d58782985
Source dataset
uspto-grants-2009_01
Patent number
US07482341B2

Reaction notes

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