Sodium Hydroxide → 6-(3-Fluoro-benzyloxymethyl)-pyridin-2-ylamine

HRID 1454878Notes

Reaction equation

HRID 1454878 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:21]=[CH:22][CH:23]=1)[CH2:5][O:6][CH2:7][C:8]1[N:13]=[C:12]([NH:14]C(=O)C(C)(C)C)[CH:11]=[CH:10][CH:9]=1.[OH-].[Na+]>>[F:1][C:2]1[CH:3]=[C:4]([CH:21]=[CH:22][CH:23]=1)[CH2:5][O:6][CH2:7][C:8]1[N:13]=[C:12]([NH2:14])[CH:11]=[CH:10][CH:9]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 68840849HCID 68840849, compound

Product 1

HCID 688407816-(3-Fluoro-benzyloxymethyl)-pyridin-2-ylamine

Procedure

This material was prepared in analogy to example 86 step B] from N-[6-(3-fluoro-benzyloxymethyl)-pyridin-2-yl]-2,2-dimethyl-propionamide (0.663 g) and 3M aqueous NaOH (4.19 mL) as a brown liquid (0.596 g). MS (ESI): 233.2 (MH+).

Sources & evidence

ORD record
ord-932146cd13464a5aa0d55d0794887223
Source dataset
uspto-grants-2009_01
Patent number
US07482341B2

Reaction notes

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