2,4-Difluorobenzenesulfonyl Chloride → 2,4-Difluoro-N-[6-(3-fluoro-benzyloxymethyl)-pyridin-2-yl]-benzenesulfonamide

HRID 1454879Notes

Reaction equation

HRID 1454879 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:15]=[CH:16][CH:17]=1)[CH2:5][O:6][CH2:7][C:8]1[N:13]=[C:12]([NH2:14])[CH:11]=[CH:10][CH:9]=1.[F:18][C:19]1[CH:24]=[C:23]([F:25])[CH:22]=[CH:21][C:20]=1[S:26](Cl)(=[O:28])=[O:27]>>[F:18][C:19]1[CH:24]=[C:23]([F:25])[CH:22]=[CH:21][C:20]=1[S:26]([NH:14][C:12]1[CH:11]=[CH:10][CH:9]=[C:8]([CH2:7][O:6][CH2:5][C:4]2[CH:15]=[CH:16][CH:17]=[C:2]([F:1])[CH:3]=2)[N:13]=1)(=[O:28])=[O:27]

Participants

3

Reactant 2

HCID 27342732,4-Difluorobenzenesulfonyl ChlorideHCID 688407816-(3-Fluoro-benzyloxymethyl)-pyridin-2-ylamine

Product 1

HCID 688456112,4-Difluoro-N-[6-(3-fluoro-benzyloxymethyl)-pyridin-2-yl]-benzenesulfonamide

Procedure

This material was prepared in analogy to example 1 from 6-(3-fluoro-benzyloxymethyl)-pyridin-2-ylamine (0.06 g) and 2,4-difluoro-benzenesulfonyl chloride (0.06 g) as a yellow solid(0.07 g). MS (ESI−): 407.2 ([M−H]−).

Sources & evidence

ORD record
ord-0fdfe9528efc41618954af29e78e6371
Source dataset
uspto-grants-2009_01
Patent number
US07482341B2

Reaction notes

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