3-Chlorobenzenesulphonyl chloride → 3-Chloro-N-[6-(3-fluoro-benzyloxymethyl)-pyridin-2-yl]-benzenesulfonamide

HRID 1454880Notes

Reaction equation

HRID 1454880 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:15]=[CH:16][CH:17]=1)[CH2:5][O:6][CH2:7][C:8]1[N:13]=[C:12]([NH2:14])[CH:11]=[CH:10][CH:9]=1.[Cl:18][C:19]1[CH:20]=[C:21]([S:25](Cl)(=[O:27])=[O:26])[CH:22]=[CH:23][CH:24]=1>>[Cl:18][C:19]1[CH:20]=[C:21]([S:25]([NH:14][C:12]2[CH:11]=[CH:10][CH:9]=[C:8]([CH2:7][O:6][CH2:5][C:4]3[CH:15]=[CH:16][CH:17]=[C:2]([F:1])[CH:3]=3)[N:13]=2)(=[O:27])=[O:26])[CH:22]=[CH:23][CH:24]=1

Participants

3

Reactant 2

HCID 179093-Chlorobenzenesulphonyl chlorideHCID 688407816-(3-Fluoro-benzyloxymethyl)-pyridin-2-ylamine

Product 1

HCID 688455473-Chloro-N-[6-(3-fluoro-benzyloxymethyl)-pyridin-2-yl]-benzenesulfonamide

Procedure

This material was prepared in analogy to example 1 from 6-(3-fluoro-benzyloxymethyl)-pyridin-2-ylamine (0.06 g) and 3-chloro-benzenesulfonyl chloride (0.06 g) as a yellow gum (0.07 g). MS (ESI−): 405.1 ([M−H]−).

Sources & evidence

ORD record
ord-34ff2639c735462a8a9b821992ef2820
Source dataset
uspto-grants-2009_01
Patent number
US07482341B2

Reaction notes

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