2,4-Dichloro-6-methylbenzenesulfonyl chloride → 2,4-Dichloro-N-[6-(4-fluoro-benzyloxymethyl)-pyridin-2-yl]-6-methyl-benzenesulfonamide
Reaction equation
[F:1][C:2]1[CH:17]=[CH:16][C:5]([CH2:6][O:7][CH2:8][C:9]2[N:14]=[C:13]([NH2:15])[CH:12]=[CH:11][CH:10]=2)=[CH:4][CH:3]=1.[Cl:18][C:19]1[CH:24]=[C:23]([Cl:25])[CH:22]=[C:21]([CH3:26])[C:20]=1[S:27](Cl)(=[O:29])=[O:28]>>[Cl:18][C:19]1[CH:24]=[C:23]([Cl:25])[CH:22]=[C:21]([CH3:26])[C:20]=1[S:27]([NH:15][C:13]1[CH:12]=[CH:11][CH:10]=[C:9]([CH2:8][O:7][CH2:6][C:5]2[CH:4]=[CH:3][C:2]([F:1])=[CH:17][CH:16]=2)[N:14]=1)(=[O:29])=[O:28]Participants
3
Procedure
This material was prepared in analogy to example 1 from 6-(4-fluoro-benzyloxymethyl)-pyridin-2-ylamine (0.07 g) and 2,4-dichloro-6-methyl-benzenesulfonyl chloride (0.086 g) as a light yellow solid (0.11 g). MS (ESI−): 453.1 ([M−H]−).
Sources & evidence
- ORD record
- ord-68723f8d811c40269c7faeef2f616760
- Source dataset
- uspto-grants-2009_01
- Patent number
- US07482341B2
Reaction notes
Loading…