Sodium hydride → HCID 68842009, compound

Participants

Reaction Steps

3,3,3-Trifluoro-propan-1-ol (0.214 g) in THF (8 mL) was treated under an argon atmosphere with sodium hydride (0.1 g, 60% suspension in oil) and stirred for 1 h at RT. N-(6-chloromethyl-pyridin-2-yl)-2,2-dimethyl-propionamide, 0.142 g, product of example 120 step A], was added and the mixture was heated at 85° C. for 2.5 h. The reaction mixture was cooled, partitioned between ice water and AcOEt, the layers were separated, the organic layer dried over Na2SO4, filtered and evaporated to give 2,2-dimethyl-N-[6-(3,3,3-trifluoro-propoxymethyl)-pyridin-2-yl]-propionamide (0.21 g) as a light brown oil. MS (ESI): 305.3 (MH+).

Provenance & Evidence