3-(Trifluoromethyl)benzenesulfonyl chloride → 3-Trifluoromethyl-N-[6-(3,3,3-trifluoro-propoxymethyl)-pyridin-2-yl]-benzenesulfonamide

HRID 1454889Notes

Reaction equation

HRID 1454889 reaction equation
[F:1][C:2]([F:15])([F:14])[CH2:3][CH2:4][O:5][CH2:6][C:7]1[N:12]=[C:11]([NH2:13])[CH:10]=[CH:9][CH:8]=1.[F:16][C:17]([F:29])([F:28])[C:18]1[CH:19]=[C:20]([S:24](Cl)(=[O:26])=[O:25])[CH:21]=[CH:22][CH:23]=1>>[F:29][C:17]([F:16])([F:28])[C:18]1[CH:19]=[C:20]([S:24]([NH:13][C:11]2[CH:10]=[CH:9][CH:8]=[C:7]([CH2:6][O:5][CH2:4][CH2:3][C:2]([F:1])([F:14])[F:15])[N:12]=2)(=[O:25])=[O:26])[CH:21]=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 27332503-(Trifluoromethyl)benzenesulfonyl chlorideHCID 688426152-Pyridinamine, 6-[(3,3,3-trifluoropropoxy)methyl]-

Product 1

HCID 866042403-Trifluoromethyl-N-[6-(3,3,3-trifluoro-propoxymethyl)-pyridin-2-yl]-benzenesulfonamide

Procedure

This material was prepared in analogy to example 1 from 6-(3,3,3-Trifluoro-propoxymethyl)-pyridin-2-ylamine (0.075 g) and 3-(trifluoromethyl)-benzenesulfonyl chloride (0.092 g) as a light yellow gum (0.048 g). MS (ESI−): 427.1 ([M−H]−).

Sources & evidence

ORD record
ord-5fd55df50b254df9b4d2d32dd9bd5bb4
Source dataset
uspto-grants-2009_01
Patent number
US07482341B2

Reaction notes

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