2,4-Dichloro-6-methylbenzenesulfonyl chloride → 2,4-Dichloro-6-methyl-N-[6-(3,3,3-trifluoro-propoxymethyl)-pyridin-2-yl]-benzenesulfonamide

HRID 1454890Notes

Reaction equation

HRID 1454890 reaction equation
[F:1][C:2]([F:15])([F:14])[CH2:3][CH2:4][O:5][CH2:6][C:7]1[N:12]=[C:11]([NH2:13])[CH:10]=[CH:9][CH:8]=1.[Cl:16][C:17]1[CH:22]=[C:21]([Cl:23])[CH:20]=[C:19]([CH3:24])[C:18]=1[S:25](Cl)(=[O:27])=[O:26]>>[Cl:16][C:17]1[CH:22]=[C:21]([Cl:23])[CH:20]=[C:19]([CH3:24])[C:18]=1[S:25]([NH:13][C:11]1[CH:10]=[CH:9][CH:8]=[C:7]([CH2:6][O:5][CH2:4][CH2:3][C:2]([F:1])([F:14])[F:15])[N:12]=1)(=[O:27])=[O:26]

Participants

3

Reactant 2

HCID 28013872,4-Dichloro-6-methylbenzenesulfonyl chlorideHCID 688426152-Pyridinamine, 6-[(3,3,3-trifluoropropoxy)methyl]-

Product 1

HCID 688453792,4-Dichloro-6-methyl-N-[6-(3,3,3-trifluoro-propoxymethyl)-pyridin-2-yl]-benzenesulfonamide

Procedure

This material was prepared in analogy to example 1 from 6-(3,3,3-Trifluoro-propoxymethyl)-pyridin-2-ylamine (0.075 g) and 2,4-dichloro-6-methyl-benzenesulfonyl chloride (0.097 g) as a light yellow gum (0.08 g). MS (ESI−): 441.1 ([M−H]−).

Sources & evidence

ORD record
ord-18ff7ae5133e41459dbfc4b3388a7ea2
Source dataset
uspto-grants-2009_01
Patent number
US07482341B2

Reaction notes

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