3-(Trifluoromethyl)benzenesulfonyl chloride → n-[6-(2-Cyclopropyl-ethoxymethyl)-pyridin-2-yl]-3-trifluoromethyl-benzenesulfonamide

HRID 1454896Notes

Reaction equation

HRID 1454896 reaction equation
[CH:1]1([CH2:4][CH2:5][O:6][CH2:7][C:8]2[N:13]=[C:12]([NH2:14])[CH:11]=[CH:10][CH:9]=2)[CH2:3][CH2:2]1.[F:15][C:16]([F:28])([F:27])[C:17]1[CH:18]=[C:19]([S:23](Cl)(=[O:25])=[O:24])[CH:20]=[CH:21][CH:22]=1>>[CH:1]1([CH2:4][CH2:5][O:6][CH2:7][C:8]2[N:13]=[C:12]([NH:14][S:23]([C:19]3[CH:20]=[CH:21][CH:22]=[C:17]([C:16]([F:15])([F:27])[F:28])[CH:18]=3)(=[O:25])=[O:24])[CH:11]=[CH:10][CH:9]=2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 27332503-(Trifluoromethyl)benzenesulfonyl chlorideHCID 688421766-(2-Cyclopropyl-ethoxymethyl)-pyridin-2-ylamine

Product 1

HCID 68845612n-[6-(2-Cyclopropyl-ethoxymethyl)-pyridin-2-yl]-3-trifluoromethyl-benzenesulfonamide

Procedure

This material was prepared in analogy to example 1 from 6-(2-cyclopropyl-ethoxymethyl)-pyridin-2-ylamine (0.08 g) and 3-(trifluormethyl)-benzenesulfonyl chloride (0.11 g) as a light yellow gum (0.106 g). MS (ESI−): 399.2 ([M−H]−).

Sources & evidence

ORD record
ord-409e46052b1846118df860189fa43262
Source dataset
uspto-grants-2009_01
Patent number
US07482341B2

Reaction notes

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