2,4-Dichloro-6-methylbenzenesulfonyl chloride → 2,4-Dichloro-N-[6-(2-cyclopropyl-ethoxymethyl)-pyridin-2-yl]-6-methyl-benzenesulfonamide
Reaction equation
[CH:1]1([CH2:4][CH2:5][O:6][CH2:7][C:8]2[N:13]=[C:12]([NH2:14])[CH:11]=[CH:10][CH:9]=2)[CH2:3][CH2:2]1.[Cl:15][C:16]1[CH:21]=[C:20]([Cl:22])[CH:19]=[C:18]([CH3:23])[C:17]=1[S:24](Cl)(=[O:26])=[O:25]>>[Cl:15][C:16]1[CH:21]=[C:20]([Cl:22])[CH:19]=[C:18]([CH3:23])[C:17]=1[S:24]([NH:14][C:12]1[CH:11]=[CH:10][CH:9]=[C:8]([CH2:7][O:6][CH2:5][CH2:4][CH:1]2[CH2:3][CH2:2]2)[N:13]=1)(=[O:26])=[O:25]Participants
3
Procedure
This material was prepared in analogy to example 1 from 6-(2-cyclopropyl-ethoxymethyl)-pyridin-2-ylamine (0.08 g) and 2,4-dichloro-6-methyl-benzenesulfonyl chloride (0.117 g) as a light yellow gum (0.088 g). MS (ESI−): 413.1 ([M−H]−).
Sources & evidence
- ORD record
- ord-9fcf9e27f0a541c792a58377c889cc5d
- Source dataset
- uspto-grants-2009_01
- Patent number
- US07482341B2
Reaction notes
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