2-Chloro-5-(trifluoromethyl)benzene-1-sulfonyl chloride → 2-Chloro-N-[6-(2,2,2-trifluoro-ethoxymethyl)-pyridin-2-yl]-5-trifluoromethyl-benzenesulfonamide

HRID 1454900Notes

Reaction equation

HRID 1454900 reaction equation
[F:1][C:2]([F:14])([F:13])[CH2:3][O:4][CH2:5][C:6]1[N:11]=[C:10]([NH2:12])[CH:9]=[CH:8][CH:7]=1.[Cl:15][C:16]1[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][C:17]=1[S:26](Cl)(=[O:28])=[O:27]>>[Cl:15][C:16]1[CH:21]=[CH:20][C:19]([C:22]([F:24])([F:23])[F:25])=[CH:18][C:17]=1[S:26]([NH:12][C:10]1[CH:9]=[CH:8][CH:7]=[C:6]([CH2:5][O:4][CH2:3][C:2]([F:1])([F:13])[F:14])[N:11]=1)(=[O:28])=[O:27]

Participants

3

Reactant 2

HCID 27342742-Chloro-5-(trifluoromethyl)benzene-1-sulfonyl chlorideHCID 688453756-(2,2,2-Trifluoro-ethoxymethyl)-pyridin-2-ylamine

Product 1

HCID 866042422-Chloro-N-[6-(2,2,2-trifluoro-ethoxymethyl)-pyridin-2-yl]-5-trifluoromethyl-benzenesulfonamide

Procedure

This material was prepared in analogy to example 1 from 6-(2,2,2-Trifluoro-ethoxymethyl)-pyridin-2-ylamine (0.08 g) and 2-chloro-5-(trifluoromethyl)- benzenesulfonyl chloride (0.119 g) as alight yellow solid (0.123 g). MS (ESI−): 447.0 ([M−H]−).

Sources & evidence

ORD record
ord-49af4746fae947ec82d6affbc59dd380
Source dataset
uspto-grants-2009_01
Patent number
US07482341B2

Reaction notes

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