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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1454905Generated: October 31, 2026

1-(Bromomethyl)-4-chlorobenzene → N-[6-(4-Chloro-benzyloxymethyl)-pyridin-2-yl]-2,2-dimethyl-propionamide

https://huagongshe.com/reaction/1454905

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(Bromomethyl)-4-chlorobenzeneHCID 69329—
ReactantN-[6-(Hydroxymethyl)pyridin-2-yl]-2,2-dimethylpropanamideHCID 21782926—
ProductN-[6-(4-Chloro-benzyloxymethyl)-pyridin-2-yl]-2,2-dimethyl-propionamideHCID 68842149—

Reaction Steps

This material was prepared in analogy to example 86 step A] from N-(6-hydroxymethyl-pyridin-2-yl)-2,2-dimethyl-propionamide (0.73 g) and 4-chlorobenzyl bromide as a yellow oil (0.868 g). MS (ESI): 332.2 (MH+).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07482341B2
Source datasetuspto-grants-2009_01
ORD IDord-58698a7a3db342b5a60c237c626d9098
Source noteuspto-grants-2009_01