Sodium Hydroxide → 6-(4-Chloro-benzyloxymethyl)-pyridin-2-ylamine

HRID 1454906Notes

Reaction equation

HRID 1454906 reaction equation
[Cl:1][C:2]1[CH:23]=[CH:22][C:5]([CH2:6][O:7][CH2:8][C:9]2[N:14]=[C:13]([NH:15]C(=O)C(C)(C)C)[CH:12]=[CH:11][CH:10]=2)=[CH:4][CH:3]=1.[OH-].[Na+]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][O:7][CH2:8][C:9]2[N:14]=[C:13]([NH2:15])[CH:12]=[CH:11][CH:10]=2)=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 68842149HCID 68842149, compound

Product 1

HCID 688451046-(4-Chloro-benzyloxymethyl)-pyridin-2-ylamine

Procedure

This material was prepared in analogy to example 86 step B] from N-[6-(4-chloro-benzyloxymethyl)-pyridin-2-yl]-2,2-dimethyl-propionamide (0.868 g) and 3M aqueous NaOH (5.22 mL) as a light yellow liquid (0.63 g). MS (ESI): 249.1 (MH+).

Sources & evidence

ORD record
ord-30ee2ca94e764d10a61d1089baca3a3f
Source dataset
uspto-grants-2009_01
Patent number
US07482341B2

Reaction notes

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