2,4-Dichloro-6-methylbenzenesulfonyl chloride → 2,4-Dichloro-N-[6-(4-chloro-benzyloxymethyl)-pyridin-2-yl]-6-methyl-benzenesulfonamide

HRID 1454908Notes

Reaction equation

HRID 1454908 reaction equation
[Cl:1][C:2]1[CH:17]=[CH:16][C:5]([CH2:6][O:7][CH2:8][C:9]2[N:14]=[C:13]([NH2:15])[CH:12]=[CH:11][CH:10]=2)=[CH:4][CH:3]=1.[Cl:18][C:19]1[CH:24]=[C:23]([Cl:25])[CH:22]=[C:21]([CH3:26])[C:20]=1[S:27](Cl)(=[O:29])=[O:28]>>[Cl:18][C:19]1[CH:24]=[C:23]([Cl:25])[CH:22]=[C:21]([CH3:26])[C:20]=1[S:27]([NH:15][C:13]1[CH:12]=[CH:11][CH:10]=[C:9]([CH2:8][O:7][CH2:6][C:5]2[CH:4]=[CH:3][C:2]([Cl:1])=[CH:17][CH:16]=2)[N:14]=1)(=[O:29])=[O:28]

Participants

3

Reactant 2

HCID 28013872,4-Dichloro-6-methylbenzenesulfonyl chlorideHCID 688451046-(4-Chloro-benzyloxymethyl)-pyridin-2-ylamine

Product 1

HCID 688455932,4-Dichloro-N-[6-(4-chloro-benzyloxymethyl)-pyridin-2-yl]-6-methyl-benzenesulfonamide

Procedure

This material was prepared in analogy to example 1 from 6-(4-chloro-benzyloxymethyl)-pyridin-2-ylamine (0.08 g) and 2,4-dichloro-6-methyl-benzenesulfonyl chloride (0.092 g) as an off-white solid (0.082 g). MS (ESI−): 469.0 ([M−H]−).

Sources & evidence

ORD record
ord-50d228a5f8424462ace874df79fbcd1c
Source dataset
uspto-grants-2009_01
Patent number
US07482341B2

Reaction notes

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