Sodium hydride → HCID 16749956, compound

Participants

Reaction Steps

To a solution of NaH (20 mg, 0.83 mmol) and 2,4-difluorobenzenethiol (74 mg, 0.51 mmol), in THF 2 mL was added 2-chloro-5-(2,6-difluorophenyl)-6H-pyrido[1,2-b]pyridazin-6-one (50 mg, 0.17 mmol) as a solution in THF (1 mL). The reaction was complete in 10 min and concentrated in vacuo. The crude residue was purified via silica gel chromatography (EtOAc/CH2Cl2/MeOH) to yield the title compound.

Provenance & Evidence