Stannane, tributyl-(1Z)-1-propen-1-yl- → HCID 16749629, compound

HRID 1454974Notes

Reaction equation

HRID 1454974 reaction equation
Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:9](=[O:27])[CH:10]=[CH:11][N:12]2[C:17]=1[CH:16]=[CH:15][C:14]([O:18][C:19]1[CH:24]=[CH:23][C:22]([F:25])=[CH:21][C:20]=1[F:26])=[N:13]2.[CH3:28][CH2:29][CH2:30]C[Sn](/C=C/C)(CCCC)CCCC>>[F:26][C:20]1[CH:21]=[C:22]([F:25])[CH:23]=[CH:24][C:19]=1[O:18][C:14]1[CH:15]=[CH:16][C:17]2[N:12]([CH:11]=[CH:10][C:9](=[O:27])[C:8]=2[C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2/[CH:28]=[CH:29]/[CH3:30])[N:13]=1

Participants

3

Reactant 2

HCID 5315049Stannane, tributyl-(1Z)-1-propen-1-yl-HCID 16749610HCID 16749610, compound

Product 1

HCID 16749629HCID 16749629, compound

Procedure

The title compound was prepared from 5-(2-bromophenyl)-2-(2,4-difluorophenoxy)-6H-pyrido[1,2-b]pyridazin-6-one as described in Example-7 using tri-N-butyl(1-propenyl)tin in place of tri-N-butyl (vinyl)tin. 50/50 mixture of cis and trans.

Workup

  1. addition50/50 mixture of cis and trans

Sources & evidence

ORD record
ord-33ef33a2b0834938b6b198c3507b6c8b
Source dataset
uspto-grants-2009_01
Patent number
US07482345B2

Reaction notes

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