Acetic Acid → HCID 178461796, compound

HRID 1454998Notes

Reaction equation

HRID 1454998 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([SH:8])[N:5]=[C:4]([OH:9])[CH:3]=1.CC(O)=O.N[C@@H:15]([CH2:17][OH:18])[CH3:16]>O>[OH:18][CH2:17][C@H:15]([NH:1][C:2]1[N:7]=[C:6]([SH:8])[N:5]=[C:4]([OH:9])[CH:3]=1)[CH3:16]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 80308(R)-(-)-2-Amino-1-propanolHCID 178507961HCID 178507961, compound

Product 1

HCID 178461796HCID 178461796, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
50 °C

Procedure

6-Amino-2-mercapto-4-pyrimidinol (16.1 g), AcOH (14.3 ml) and (R)-Alaninol (39 ml) were heated at 170° C. for 5 h. The mixture was cooled to approximately 50° C., diluted with water (500 ml) and cooled at 0° C. for 20 h. The resulting solid was filtered, washed with water and dried in vacuo to yield a mixture of subtitle product and starting material (2:1) as a cream coloured solid. Yield 7.2 g.

Workup

  1. temperaturecooled at 0° C. for 20 h
  2. filtrationThe resulting solid was filtered
  3. washwashed with water
  4. customdried in vacuo
  5. customto yield

Sources & evidence

ORD record
ord-3b559c78f3c644c783e551eff5577ce5
Source dataset
uspto-grants-2009_01
Patent number
US07482355B2

Reaction notes

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