Sodium Hydroxide → 2-[[(2,3-Difluorophenyl)methyl]thio]-4,6(1H,5H)-pyrimidinedione

Participants

Reaction Conditions

Reaction Steps

Sodium hydroxide (6.1 g) in ethanol (20 ml) and water (20 ml) was added to a suspension of 4,6-dihydroxy-2-thiopyrimidine in ethanol/water (120 ml/120 ml). 2,3-difluorobenzyl bromide (28.4 g) was added dropwise to this solution. The mixture was heated at 60° C. for 2 h and stirred at room temperature for 20 h. The solids were filtered and washed with water (200 ml), isopropanol (20 ml) and dried in vacuo at 40° C. for 24 h to yield the subtitle compound. Yield 31.0 g.

Provenance & Evidence