Imidazole → HCID 86602451, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of the subtitle product of step i) (5.60 g) in DMF was added tert-butyldimethylsilyl chloride (2.40 g) at −10° C. in portions. To this mixture was then added imidazole in portions. The mixture was then stirred at 0° C. for 2 h before being quenched with excess water. The mixture was then extracted with EtOAc (2×250 ml), the combined organics washed with water (3×300 ml) and brine (2×30 ml). The organic layer was dried (MgSO4) and solid was filtered. The filtrate was evaporated to dryness. The residue was purified by column chromatography (10% EtOAc/isohexane) to yield the subtitle compound as a white solid.

Provenance & Evidence