HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Hydroxybenzaldehyde → 6-Hydroxy-2-(3-hydroxyphenyl)chroman-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Hydroxybenzaldehyde | HCID 101 | — |
| Reactant | 2-(4-Fluorophenyl)-6-hydroxychroman-4-one | HCID 17978541 | — |
| Product | 6-Hydroxy-2-(3-hydroxyphenyl)chroman-4-one | HCID 12291478 | — |
Reaction Steps
6-Hydroxy-2-(3-hydroxyphenyl)chroman-4-one was prepared as described for 6-hydroxy-2-(4-fluorophenyl)chroman-4-one in Example 2(a) but starting from 3-hydroxybenzaldehyde. The product was recrystallised from ethanol. 1H NMR (400 MHz, d6-DMSO) δ: 9.50 (bs, 1H), 9.41 (bs, 1H), 7.22-7.17 (m, 1H), 7.11 (d, 1H, J 3.0 Hz), 7.03 (dd, 1H J 3.0, 8.9 Hz), 6.64 (d, 1H, J 8.9 Hz), 6.92-6.90 (m, 2H), 6.76-6.73 (m, 1H), 5.46 (dd, 1H J 2.9, 12.7 Hz), 3.09 (dd, 1H, J 12.7, 16.9 Hz), 2.75 (dd, 1H, J 2.9, 16.9 Hz).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07482340B2 |
| Source dataset | uspto-grants-2009_01 |
| ORD ID | ord-668fe79ae8b444d88fcd2394309cb8c9 |
| Source note | uspto-grants-2009_01 |