HCID 86608644, compound → HCID 69015839, compound

HRID 1455054Notes

Reaction equation

HRID 1455054 reaction equation
[C:1]1([CH:7]2[CH2:16][CH2:15][C:14]3[C:9](=[CH:10][CH:11]=[C:12]([O:17][C:18]4[N:23]=[CH:22][C:21]([NH2:24])=[CH:20][CH:19]=4)[CH:13]=3)[O:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.N1CCC(C(O)=O)CC1.C([O:38][C:39](=[O:50])[C@@H:40]([NH:46]C(O)=O)[CH2:41][CH2:42][C:43](O)=[O:44])(C)(C)C>>[NH2:46][C@@H:40]([CH2:41][CH2:42][C:43](=[O:44])[NH:24][C:21]1[CH:22]=[N:23][C:18]([O:17][C:12]2[CH:13]=[C:14]3[C:9](=[CH:10][CH:11]=2)[O:8][CH:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH2:16][CH2:15]3)=[CH:19][CH:20]=1)[C:39]([OH:50])=[O:38]

Participants

3

Reactant 2

HCID 86608644HCID 86608644, compoundHCID 86608646HCID 86608646, compound

Product 1

HCID 69015839HCID 69015839, compound

Procedure

(S)-2-Amino-4-[6-(2-phenylchroman-6-yloxy)pyridin-3-ylcarbamoyl]butyric acid was prepared as described for piperidine-4-carboxylic acid [6-(2-phenyl-chroman-6-yloxy)pyridine-3-yl]amine in Example 19 a) and b) but replacing N-(tert-butoxycarbonyl)isonipecotic acid with (S)-2-carboxyaminopentanedioic acid 1-tert-butyl ester.

Sources & evidence

ORD record
ord-ce9c29557b06467bacede2bdca58ec9b
Source dataset
uspto-grants-2009_01
Patent number
US07482340B2

Reaction notes

Loading…