Hydrochloric Acid → Methyl 6-chloropyridine-3-carboxylate

Participants

Reaction Steps

6-Chloronicotinic acid (2.0 g) was dissolved in methanol and concentrated hydrochloric acid (3.0 ml) was added. The reaction mixture was refluxed for 5 hours and methanol was removed in vacuum. Ethyl acetate was added and the resulting solution was washed with saturated sodium bicarbonate solution, water and brine. 1H NMR (400 MHz,) δ: 8.92 (d, 1H, J 2.1 Hz), 8.32 (dd, 1H, J 8.4, 2.1 Hz), 7.70 (d, 1H, J 8.4 Hz), 3.90 (s, 3H).

Provenance & Evidence