HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (1S)-2-morpholin-4-yl-2-oxo-1-phenylethylamine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | N-(tert-butoxycarbonyl)-(1S)-2-morpholin-4-yl-2-oxo-1-phenylethylamine | HCID 57444168 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (1S)-2-morpholin-4-yl-2-oxo-1-phenylethylamine hydrochloride | HCID 45158390 | 90% |
Reaction Steps
1.327 g of N-(tert-butoxycarbonyl)-(1S)-2-morpholin-4-yl-2-oxo-1-phenylethylamine was dissolved in 15 mL of dioxane and treated with 3.5 mL of HCl 4 M in dioxane overnight. The solvent was removed and the solid was triturated with diethylether yielding 920 mg of the product (yield 90%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07482354B2 |
| Source dataset | uspto-grants-2009_01 |
| ORD ID | ord-e61cba990c6044058158a9a347d7d0a9 |
| Source note | uspto-grants-2009_01 |