Benzonitrile → HCID 68913860, compound

Participants

Reaction Steps

The benzonitrile of Preparation 1 (7.2 g, 33 mmol) was dissolved in acetic acid (70 ml). Hydrazine hydrate (1.9 ml, 39.7 mmol) was then added, and the reaction mixture was stirred at room temperature for 1 hour, under nitrogen. It was then concentrated under reduced pressure, and the residue was purified by flash chromatography on silica gel eluting with dichloromethane:ethyl acetate (3:1 then 1:1, by volume) to provide the title compound (4.09 g, 88%) as a pale yellow solid.

Provenance & Evidence