Iodine → HCID 68917779, compound

Participants

Reaction Steps

Iodine (243 mg, 0.95 mmol) was added portionwise to a solution of triphenylphosphine (250 mg, 0.95 mmol) in dichloromethane (10 ml). The reaction mixture was then stirred for 10 minutes, after which time triethylamine (194 mg, 1.9 mmol) was added, followed by the acetylacetohydrazide of step (b) above (170 mg, 0.48 mmol). The reaction mixture was then stirred at room temperature for 12 hours after which time it was evaporated to dryness and purified by flash chromatography on silica gel eluting with ethyl acetate:pentane (1:1, by volume) to provide the title compound (80 mg, 49%) as 4:1 mixture product:triphenylphosphine oxide.

Provenance & Evidence